GM0015 Human MDR1
GM0004 Mouse Mdr1a
GM0016 Mouse Mdr1b
GM0010 Human MRP1
GM0011 Rat Mrp1
GM0017 Dog Mrp1
GM0001 Human MRP2
GM0002 Rat Mrp2
GM0014 Dog Mrp2
GM0022 Mouse Mrp2
GM0018 Monkey Mrp2
GM0021 Human MRP3
GM0012 Human MRP4
GM0020 Rat Mrp4
GM0013 Human MRP8
GM0008 Human BCRP
GM0007 Rat Bcrp
GM0005 Human BSEP
GM0006 Rat Bsep
GM0019 Dog Bsep
GM0003 Control
Reagent Kit for BSEP GM3001
Reagent Kit for MRPs GM3010
Reagent Kit for MDR1 GM3030
MRP1
MRP2
MRP3
MRP4
MRP8
BSEP
BCRP
Control
Update:2024.5.10
Vesicular Transport Assay Reagent Kit
ABC Transporter Products
Products Lineup
ABC Transporter Products
GenoMembrane has excellent expertise and experience in the production of various drug transporters. We provide"ABC Transporter Vesicles", which are prepared from insect Sf9 cells expressing various ABC transporters.
ATPase assay and vesicular transport assay using our products are helpful to clarify the interactions between a compound of interest and ABC transporters.
・One vial of the vesicle producuts can perform 125 ATPase assays and 50 vesicular transport assays.
・The product size of all the products below is same. (2.5 mg/0.5 ml/vial)
・The products are suitable for in vitro screening of transporter substrates in a 96-well plate format.
・These products are expected to be useful tools for absorption, distribution, metabolism and excretion (ADME) and toxicological studies during drug development, as well as for studies on drug resistance mechanisms of anti-cancer drugs.
Products
A recent trend in drug development is to create new drugs that target a specific molecule identified by means of a genomic approach. Nevertheless, many drugs fail to reach clinical application, and costs associated with such unsuccessful drugs are high.
One of the major reasons for drop-out is inappropriate ADME (absorption, distribution, metabolism, and excretion) properties ofcandidates, resulting in low bioavailability or toxicity. It is, therefore, important to predict such problems at as early a stage as possible in the development process. GenoMembrane provides transporter reagents for this purpose.
GenoMembrane provides Transporter Membrane Vesicles and transporter expressing cell lines as research reagents.
MDR1
